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287548

Impact of Degeneration of the Prelimbic and Infralimbic Cortices on Psychomotor Activity and Cognitive Func-tion in Rats Stereotaxically Injected with Ibotenate

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Last updated: 04 Jan 2025

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Basic Research

Abstract

Background: Little is understood about how mild cognitive impairment affects motor function (MCI). Memory and psychomotor functions are assumed to be regulated by the medial prefrontal cortex (mPFC). The mPFC consists of a total of three distinct subareas. Thus, the purpose of this work was to specifically damage the prelimbic (PrL) and infralimbic (IFL) subareas utilizing a rodent stereotaxis injection of a relatively low dose of ibotenate. Aim: to investigate the impact of the PrL and IFL subareas lesions on psychomotor activities and memory among stereotaxically injected rats with ibotenate. Materials and Methods: For this study, a total of 36 white albino rats were employed. Three groups were designed: the normal control group (GI), the bilateral sham group (GII) which included injected rats with phosphate-buffered saline (PBS) in the PrL and IL subareas, and the bilateral lesioned group (GIII) which included injected rats with ibotenate in the PrL and IL cortices. Then rats were undergone through the open field test (OFT) and hole board test (HB). Transcardial perfusion and brain extraction for tissue preparation and histological evaluation were done at the end of the experiment. Results: the group with bilateral PrL and IFL lesions had intact psychomotor functions and spatial reference memory, but they started to lose short-term memory. Conclusions: PrL and IFL subareas of the mPFC degeneration don't impair psychomotor functions or spatial reference memory but can impact short-term memory in rats.
Keywords:mild cognitive impairment, medial prefrontal cortex, rodent stereotaxis, ibotenate

DOI

10.21608/scumj.2023.287548

Keywords

Mild Cognitive Impairment, medial prefrontal cortex, rodent stereotaxis, ibotenate

Authors

First Name

Meran

Last Name

Mostafa

MiddleName

-

Affiliation

Human Physiology Department, Faculty of Medicine, Suez Canal University.

Email

meranmostafa@med.suez.edu.eg

City

Ismailia

Orcid

-

First Name

Mona

Last Name

Mansour

MiddleName

-

Affiliation

Human Physiology Department, Faculty of Medicine, Suez Canal University.

Email

mona_mansour@med.suez.edu.eg

City

-

Orcid

-

First Name

Hani

Last Name

Hafez

MiddleName

S.

Affiliation

Zoology Department, Faculty of Science, Suez University, Egypt.

Email

hani.hafez@suezuniv.edu.eg

City

-

Orcid

-

First Name

Faten

Last Name

Abbas

MiddleName

-

Affiliation

Human Physiology Department, Faculty of Medicine, Suez Canal University.

Email

-

City

-

Orcid

-

Volume

26

Article Issue

1

Related Issue

39420

Issue Date

2023-01-01

Receive Date

2023-02-26

Publish Date

2023-01-01

Page Start

82

Page End

91

Print ISSN

1110-6999

Online ISSN

2090-2581

Article File

SCUMJ_Volume 26_Issue 1_Pages 82-91.pdf

PDF . 890.8kB

Link

https://scumj.journals.ekb.eg/article_287548.html

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https://scumj.journals.ekb.eg/service?article_code=287548

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Original Article

Type Code

938

Publication Type

Journal

Publication Title

Suez Canal University Medical Journal

Publication Link

https://scumj.journals.ekb.eg/

MainTitle

Impact of Degeneration of the Prelimbic and Infralimbic Cortices on Psychomotor Activity and Cognitive Func-tion in Rats Stereotaxically Injected with Ibotenate

Details

Type

Article

Created At

24 Dec 2024