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284236

Tissue Expression of Nuclear Factor Kappa Beta in Psoriasis Vulgaris Before and After Psoralen Ultraviolet-A Therapy: A Prospective Study

Article

Last updated: 24 Dec 2024

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-

Tags

Clinical Research (Medical)

Abstract

Background:Nuclear factor kappa beta is an inducible nuclear transcription factor regulating a range of cellular processes. Nuclear factor kappa beta is considered to impact many cellular phenomena such as inflammation, immune responses, proliferation, differentiation, apoptosis, and tumor progression, therefore considered to have a major role in many inflammatory skin diseases including the pathogenesis of psoriasis. Aim: This study aims to investigate nuclear factor kappa beta tissue expression in patients with psoriasis vulgaris before and after Psoralen Ultraviolet A therapy. Subjects and Methods: Thirty patients with generalized chronic plaque psoriasis were assigned as a test group (Group I) and 10 age-and sex-matched healthy individuals assigned as a control group (Group II) were enrolled in this study. Skin biopsy specimens were subjected to histopathological study and immunohistochemical determination ofnuclear factor kappa beta before and after 30 sessions of Psoralen Ultraviolet A therapy. Results: This study revealed highly constitutive tissue expression ofnuclear factor kappa beta in all psoriatic lesions with variable degrees in comparison with control specimens (p < 0.001). Also, there was a significant decrease in nuclear factor kappa beta expressionin psoriatic skin after Psoralen Ultraviolet A therapy (p < 0.001).Conclusion:Psoralen Ultraviolet A therapy among psoriatic patients demonstrated a decrease in PASI score, epidermal thickness; mononuclear cellular infiltration, as well as nucleocytoplasmic positivity (active nuclear factor kappa beta form) expression, accordingly selective blockade of nuclear factor kappa beta could be an effective treatment for psoriasis.
 

DOI

10.21608/scumj.2023.284236

Keywords

Nuclear factor kappa beta, Psoriasis, Psoralen Ultraviolet A

Authors

First Name

Hesham

Last Name

Nada

MiddleName

-

Affiliation

Department of Dermatology and Venereology, Faculty of Medicine, Suez Canal University, Ismailia, Egypt

Email

profheshamnada@gmail.com

City

Ismailia

Orcid

0000 0001 7094 5462

First Name

Sherine

Last Name

El-Saman

MiddleName

-

Affiliation

Department of Dermatology and Venereology, Faculty of Medicine, Suez Canal University, Ismailia, Egypt

Email

-

City

-

Orcid

-

First Name

Abeer

Last Name

Mohamed

MiddleName

-

Affiliation

Department of Histology, Faculty of Medicine, Suez Canal University, Ismailia, Egypt

Email

abeermohamed@gmail.com

City

-

Orcid

-

Volume

26

Article Issue

1

Related Issue

39420

Issue Date

2023-01-01

Receive Date

2023-02-06

Publish Date

2023-01-01

Page Start

61

Page End

69

Print ISSN

1110-6999

Online ISSN

2090-2581

Article File

SCUMJ_Volume 26_Issue 1_Pages 61-69.pdf

PDF . 412.4kB

Link

https://scumj.journals.ekb.eg/article_284236.html

Detail API

https://scumj.journals.ekb.eg/service?article_code=284236

Order

7

Type

Original Article

Type Code

938

Publication Type

Journal

Publication Title

Suez Canal University Medical Journal

Publication Link

https://scumj.journals.ekb.eg/

MainTitle

Tissue Expression of Nuclear Factor Kappa Beta in Psoriasis Vulgaris Before and After Psoralen Ultraviolet-A Therapy: A Prospective Study

Details

Type

Article

Created At

24 Dec 2024