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284001

Tissue Expression of Protease Activated Receptor 2 in Patients with Pruritus in Chronic Kidney Disease

Article

Last updated: 24 Dec 2024

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-

Tags

Clinical Research (Medical)

Abstract

Background: Uremic pruritus has been defined as itching that is directly related to kidney disease, without any other comorbid condition that causes itching. The exact pathogenesis of uremic pruritus remains unclear but, protease-activated receptor 2 (PAR2) is claimed to have a pivotal role in the pathogenesis of uremic pruritus. Aim: Evaluation of PAR2 activity in the epidermis of patients with chronic kidney disease (CKD) complaining of pruritus. Subjects and Methods: Case-control study on 48 individuals (24 CKD patients complaining from pruritus and 24 matched healthy controls). Skin biopsy specimens from all participants were taken from a similar area of the back of forearms then immunohistochemical analysis for PAR2 activity in the epidermis was performed. Results: Data revealed that epidermal PAR-2 expression was significantly higher in CKD patients compared to healthy controls. PAR2 staining intensity in skin biopsies was moderate in 9 (37.5%) patients and strong in 15 (62.5%) patients in the cases group. On the other hand, PAR2 staining was moderate in all 24 (100%) cases in the control group which was statistically significant.Conclusion: Epidermal PAR-2 expression is increased in CKD patients with pruritus.

DOI

10.21608/scumj.2023.284001

Keywords

PAR2, Chronic Kidney Disease, pruritus

Authors

First Name

Hesham

Last Name

Nada

MiddleName

A.

Affiliation

Department of Dermatology, Venereology and Andrology, Faculty of Medicine, Suez Canal University, Egypt.

Email

profheshamnada@gmail.com

City

Ismailia

Orcid

0000 0001 7094 5462

First Name

Gamal

Last Name

Hafez

MiddleName

A.

Affiliation

Department of Pathology, Faculty of Medicine, Suez Canal University, Egypt.

Email

-

City

-

Orcid

-

First Name

Mohammed

Last Name

Keshawy

MiddleName

M.

Affiliation

Department of Internal Medicine; Nephrology division, Faculty of Medicine, Suez Canal University, Egypt

Email

-

City

-

Orcid

-

First Name

Eman

Last Name

Abdelrahman

MiddleName

G.

Affiliation

Department of Dermatology, Venereology and Andrology, Faculty of Medicine, Suez Canal University, Egypt.

Email

-

City

-

Orcid

-

Volume

26

Article Issue

1

Related Issue

39420

Issue Date

2023-01-01

Receive Date

2023-02-03

Publish Date

2023-01-01

Page Start

47

Page End

54

Print ISSN

1110-6999

Online ISSN

2090-2581

Article File

SCUMJ_Volume 26_Issue 1_Pages 47-54.pdf

PDF . 696.8kB

Link

https://scumj.journals.ekb.eg/article_284001.html

Detail API

https://scumj.journals.ekb.eg/service?article_code=284001

Order

5

Type

Original Article

Type Code

938

Publication Type

Journal

Publication Title

Suez Canal University Medical Journal

Publication Link

https://scumj.journals.ekb.eg/

MainTitle

Tissue Expression of Protease Activated Receptor 2 in Patients with Pruritus in Chronic Kidney Disease

Details

Type

Article

Created At

24 Dec 2024