The phytotoxicity of heavy metals liberal through human activities reduces crop growth and yield. The current investigation was conducted to evaluate the effect of some heavy metals; Effect of cadmium [Cd], zinc [Zn], copper [Cu] and lead [Pb] on the growth of five different wheat genotypes at different stages of growth under field conditions. The results exhibited that heavy metals have a significant effect on some growth and yield traits. Cadmium had the least significant effect on plant traits, followed by zinc, copper and lead. Wheat genotypes differed in their response to heavy metal stress. Furthermore, it can be accomplished that the wheat genotype Beni Suef 5 had the highest tolerance to metals followed by Gemmayzeh 12 and Beni Suef 6, while Sakha 94 and Misr 1 showed the least tolerance to metals. Tolerant genotypes at different growth stages can be used commercially under heavy metal stress and can also be used as donor varieties to develop promising varieties intended for agricultural production under heavy metal stress.