A study was conducted over a period of 90 days to examine the impact of varying concentrations of Biofloc (with C/N ratios of 10/1 and 15/1) and Pro-Pac (at concentrations of 250 mg/l and 500 mg/l) on the water quality, feed utilization and productive parameters of Nile tilapia (Oreochromis niloticus). The study involved placing fingerlings of equal weights in rearing plastic tanks in triplicate, each containing 100 liters of water. Sub-zero water exchange with addition of molasses excluding control tanks. The fish were nourished a diet containing 25% crude protein at a rate of 2% of their live weight daily. The outcomes of the study indicate that the water quality parameters improved significantly compared to the control. Moreover, the introduction of Biofloc and Pro-Pac at varying concentrations resulted in a noteworthy increase on average body mass of the fish, as well as their specific growth rate (SGR), when compared to the control. Additionally, the feed conversion rate, along with the efficiency of protein utilization, was found to be greater in the fish tanks administered with Biofloc and Pro-pac, as compared to the control. The addition of Biofloc and Pro-Pac caused an increase in the percentage of crude protein in the fish body, and the percentage of etheric extract also increased and ash was reduced. The beneficial effects of Biofloc and Pro-pac increased as the concentration level of these substances increased.