The investigation focused on the impacts of specific nutrients as calcium chloride (CaCl2) at 0.4 and 0.6%, zinc sulfate (ZnSO4) at 0.4 and 0.5% and boric acid (B(OH)3) at 50 and100 ppm one and two sprays on delay senescence of leaves and fruit quality of guava yield in eleven years old guava at the Qalyub area, Qalyubeia Governorate, Egypt, under randomized block design with factorial approach.‎ It was discovered in this study that there had been considerable improvements in the foliar application of CaCl2, ZnSO4 and B(OH)3 on physiological and biochemical characteristics in leaves led to an increasing in the pigments of photosynthesis, proline (Pro), total sugars content (TSC), total phenolic content (TPC) and NPK contents and a decreasing in anthocyanin (ACY), poly-phenol oxidase (PPO) and peroxidase (POD) activity which reflected positively on the quality of guava fruits and led to an increase in firmness and total soluble solids (TSS) and decrease in respiration coefficient compared with the control. . In all, the single spray was better compared to the two sprays, although the two sprays were distinguished in some cases from the single spray.