A pot experiment was conducted to study the combined effect of fertilization (organic and inorganic sources) under irrigation levels of 100% (I1) and 80% (I2) of field capacity on clay soil properties, growth parameters, water use efficiency (WUE), and nitrogen uptake efficiency (NUE) by faba bean (Vicia faba cv. Giza 843). Findings demonstrated that, in comparison to the control, the interaction impact of fertilization treatments and irrigation levels significantly improved soil organic matter, cation exchange capacity, and reduced the values of soil bulk density. Additionally, N3 treatment (50% N from chicken manure + 50% N from urea) @ 100% of field capacity gave the highest relative increase in plant height (cm), number of branches per plant, fresh weight (g pot-1), dry weight (g pot-1) and chlorophyll value, which recorded 21.24, 52.63, 42.50, 38.87, and 31.60%, respectively. Also, compared to a single application of urea (N1) or ammonium nitrate (N4), integrated organic and inorganic fertilizers @ N3 followed by N6 (50% N from chicken manure plus 50% N from ammonium nitrate) recorded the greatest significant values of NPK content and uptake. Principal component analysis (PCA) showed that the most studied soil properties, growth parameters, WUE, NUE and nutritional status of faba bean correlated with the treatments of N3 and N6 under both irrigation levels.Therefore, the integration between organic and inorganic fertilizers under good irrigation management becomes essential to enhance plant growth and improve soil properties and sustainability.