Breast cancer (BC) ranks second globally in terms of the number of deaths among women. In BC patients, testing for the estrogen receptor (ER), progesterone receptor (PR), and human epidermal growth factor receptor 2 (Her-2) is now a routine. In this study, we looked at ER, PR, and HER-2 expression in breast carcinomas and compared it to other Clinicopathological parameters. BC samples (N=96) were obtained while several factors were considered, including age, menopausal status, history of family, size of tumor, grade, lymph node involvement, metastasis, stage of cancer, and the presence of the hormone receptors ER, PR, and Her-2. Breast cancer was associated with ER, PR, and HER-2. Histopathological parameters using SPSS software version 25. Significant relationships existed between ER and age, menopausal status, family history, tumor size, grade, and lymph node involvement. There was no meaningful relationship between ER and metastasis (P = 0.263). Age, menopausal status, history of family, size of tumor, grade, lymph node involvement and metastasis are all significantly associated with PR. Age,  menopausal status, size of tumor, grade, lymph node involvement and metastasis showed a strong association with HER-2. Family history and HER-2 were not significantly associated (P = 0.123). Our study discovered a significant relationship between ER, PR, and HER-2 and BC in Egyptian females; these hormone receptors should be considered as significant prognosis indicators for determining individuals who are most likely to develop and advance BC.