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357079

Genetic evaluation of CD28 rs3116496 in Egyptian children with Type 1 Diabetes (T1D)

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Last updated: 04 Jan 2025

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Abstract

The genetic contribution of Cluster of Differentiation 28 (CD28) toward type 1 diabetes (T1D) was investigated in several ethnic groups.The genotyping of CD28 rs3116496 (+17 T/C) polymorphism was performed in the Egyptian population (101 T1D patients and 100 healthy controls) by using a single-stranded-polymorphism-PCR (SSP-PCR). Despite the comparable genetic distribution of CD28 between the two groups, patients had significantly higher CT/TT against CC than healthy individuals (P<0.05 and OR=3.63). Sodium levels were decreased in patients with the CC genotype (CD28 C/T), whereas urea levels were raised in TT genotype patients. Our present study found that there may be a link between Egyptian children's T1D risk and CD28 variants.

DOI

10.21608/rjab.2022.357079

Keywords

Keywords: Diabetic, single nucleotide polymorphisms, PCR, CD28

Authors

First Name

Yasser

Last Name

Ali

MiddleName

B.M.

Affiliation

Department of Molecular Biology, Genetic Engineering and Biotechnology Research Institute (GEBRI), University of Sadat City, Egypt.

Email

yasser.ali@gebri.usc.edu.eg

City

-

Orcid

-

First Name

Dina

Last Name

Elkera

MiddleName

R.

Affiliation

Pediatric Department, Faculty of Medicine, Tanta University, Egypt.

Email

-

City

-

Orcid

-

First Name

Basima

Last Name

Elakhras

MiddleName

A.

Affiliation

Department of Molecular Biology, Genetic Engineering and Biotechnology Research Institute (GEBRI), University of Sadat City, Egypt.

Email

basima.elakhras@gebri.usc.edu.eg

City

-

Orcid

-

First Name

Heba

Last Name

El-Mahdy

MiddleName

S.

Affiliation

Pediatric Department, Faculty of Medicine, Tanta University, Egypt.

Email

-

City

-

Orcid

-

First Name

Mohamed

Last Name

Osman

MiddleName

-

Affiliation

Department of Bioinformatics, Genetic Engineering and Biotechnology Research Institute (GEBRI), University of Sadat City, Egypt.

Email

mohamed.osman@gebri.usc.edu.eg

City

Alexandria

Orcid

-

Volume

8

Article Issue

1

Related Issue

37314

Issue Date

2022-06-01

Receive Date

2022-03-20

Publish Date

2022-06-29

Page Start

27

Page End

34

Print ISSN

2356-9433

Online ISSN

2682-3470

Article File

RJAB_Volume 8_Issue 1_Pages 27-34.pdf

PDF . 278.9kB

Link

https://rjab.journals.ekb.eg/article_357079.html

Detail API

https://rjab.journals.ekb.eg/service?article_code=357079

Order

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Type

Original Article

Type Code

890

Publication Type

Journal

Publication Title

Research Journal of Applied Biotechnology

Publication Link

https://rjab.journals.ekb.eg/

MainTitle

Genetic evaluation of CD28 rs3116496 in Egyptian children with Type 1 Diabetes (T1D)

Details

Type

Article

Created At

24 Dec 2024