Carbofuran is widely used for controlling pests on rice plant. These pesticide pollute  the environment. Cyanobacteria can be used to get rid of pesticides such as carbofuran able to remove from agricultural fields. Therefore, the main objective of this research is to assess the biodegradation of the carbofuran by Anabaena oryzae and Nostoc muscorum these are cyanobacterial strains in the rice fields which polluted by this insecticide. For determination of biodegradation carbofuran, nitrogen fixation rate, dry weight formation, total count of cyanobacteria, absorbance measurements by spectrophotometer in addition gas chromatography–mass spectrometry (GC-MS) used to perform carbofuran, residues. The data showed the ability of  cyanobacteria to degrade all components of carbofuran by cyanobacteria and the mixture of Nostoc muscorum and Anabaena oryzae had improved in dry weight and increased the nitrogen fixation in environment. Furthermore, the growth and yield for rice plant after inoculation with the mixture treatment from cyanobacterial strains  were increased compared to the control. In addition, it highlights the need for cyanobacteria application in the contaminated area is a better candidate for biological decomposition of insecticides.