Rabbits are one of the most important animals in the world, mite infestations are commonly spread among rabbits through direct skin contact or contact with the environment, causing severe economic losses. the study aimed to evaluate the effects of two plant extracts (neem and pomegranate peels) against Sarcoptes scabiei infection in rabbits. a total of 20 rabbits of locally two different breeds were grouped into 5 groups, where: the 1^st group served as a control healthy. The 2^nd group was neem treated, the 3^rd group was the pomegranate peel treated, and the 4^th group was the Ivermectin treated, the last group was the infested non treated. Growth performance, immunological parameters, antioxidant assay and tissue histopathology of the rabbit groups were evaluated to determine the efficacy of both plant extracts on S. scabiei infection. The parasitological examination of the three treated groups revealed the absence of S. scabiei in all rabbits under treatment, and there is significant improvement in immunological state and histopathological picture when compared with the infested non treated group. Conclusively, pomegranate peel and neam extracts proved their competence as a natural product against Sarcoptes scabiei infestation