The present study was conducted to evaluate the possible effects of feeding diets enriched with calcium nanoparticles (CaNPs) on growth performance, carcass characteristics, some blood parameters and bone structure of broiler chickens. A total number of 300 unsexed day-old broiler chicks (Ross 308) were randomly and equally distributed into six groups, each of  five replications. The first group was fed the basal diet and served as a control group while the 2nd, 3rd, 4th, 5th and 6th groups were fed the basal diet enriched with 0.25, 0.50, 0.75, 1.0 and 1.5g of CaNPs/kg diet, respectively. The dietary supplementation of different levels of CaNPs in the diet had a positive effect (P≤0.05) on the final LBW and total BWG of broiler chicks at 42 days of age compared to the control group, but the best results was achieved by the group fed the diet supplemented with 1.5 g/kg of the CaNPs. On the other hand, dietary supplementation of CaNPs had no significant effect on TFI and TFCR of chicks during the whole experimental period compared to control group. On the other hand, the added CaNPs at a level of 0.50 g/kg led to significantly higher levels of IgA than the other groups. While dietary supplementation with CaNPs at a level of 0.25 g/kg resulted in significantly lower level of LDL-C compared with the other groups. Thus, dietary supplementation of CaNPs can be safely used for broiler chickens without any adverse effects on their growth performance, blood parameters and bone structure.