Background: Vitiligo, a chronic idiopathic skin disease characterized by the partial or total loss of melanocytes, leads to social stigmas, distress and psychological components that impair quality of life (QoL). Aim: This study aimed to assess the QoL among vitiligo patients and identify associated factors. Research Design: A descriptive research study design assessment was utilized. Setting: The study was conducted at dermatological outpatient clinics at El-Salam & Al-Hayat hospitals affiliated with the Egypt Health Care Authority in Port Said Government. Sample: The study included all (55) vitiligo patients undergoing ultraviolet therapy at the study setting. Data Collection Tools: Two tools were utilized: a self-administered questionnaire for vitiligo patients and a vitiligo patient's quality of life scale. Results: The study found that 32.7% of vitiligo patients were aged18-<20, with 60.0% being female. Furthermore, 38.2% had secondary education, and 32.7% were employed. About 40.0% had a family history of vitiligo, and approximately 78.2% had been suffering from vitiligo for more than 12 months. Additionally, 81.8% had vitiligo on exposed area. The mean quality of life score was 2.93 ± 0.62. Conclusion: The findings indicate that the majority of vitiligo patients in the study experienced impaired QoL. Recommendations: Developing an educational program for a patient with vitiligo based on their nutritional needs to improve their quality of life. Further research studies should focus on training nursing staff working with vitiligo patients to be highly knowledgeable in managing such patients and teaching them about lifestyle modifications to improve their QOL