Background: Infertility poses a significant challenge, especially for women whose psychological wellbeing is impacted by the issue. Women struggling with infertility often experience elevated stress levels and decreased marital satisfaction. Counseling and other therapeutic interventions are highly recommended to provide support for these women. Aim: To assess the effect of peer group counselling on infertility-related stress and marital satisfaction among women undergoing intra cytoplasmic sperm injection. Subjects and method: Design: A randomized controlled trial (repeated measures design) .Setting: The researchers conducted the study at Elbasma infertility center, Elbasma hospital, Menofia governorate, Egypt. Subjects: A simple random sampling included 88 infertile women divided equally into two groups, with each group consisting of 44 infertile women. Tools: the researchers used three tools, a structured interviewing questionnaire, Newton Infertility Stress Questionnaire (NIS), and Index of marital satisfaction (IMS) scale. Results: The inferential tests showed a significant difference in mean scores of infertility-related stress between both groups after the counseling intervention (P<0.001). Additionally, there were highly significant differences in the mean satisfaction scores of the counseling group across the four study periods (P≤0.001) in contrast to insignificant changes in the control group's mean satisfaction score at the four measurements (P=0.064). Conclusion: Peer group counseling was found to be effective in reducing stress related to infertility and improving marital satisfaction in infertile women, as evidenced by post-intervention tests compared to baseline assessment. Recommendations: Peer group counseling should be integrated into the entire process of diagnosing and treating infertility in women.