Background: Patients who have heart failure need to accept health alteration and positive coping with chronic symptoms and maintain a good health-related quality of life as guaranteeing their survival. Aim: Assess the relationship between severity of symptoms, resilience and health-related quality of life for patients with congestive heart failure. Design: A descriptive, correlational design was employed.  Setting: El-Salam general hospital and Al-Nasr specialized hospital in Egypt Health care Authority hospitals in Port Said governorate. Subjects: Purposive sample of 98 patients with CHF adult patients of both sexes who agreed to participate in the research with inclusion criteria patients who had been given a one-year congestive heart failure diagnosis. Tools: Anderson Symptom Inventory, the Resilience Scale, the Patients' health-related Quality of Life, and the Patients' characteristics questionnaire. Results: The majority of the patients (66.3 %) significantly had sever level of severity and symptom interfering with patients' life, also 42.9% of them had high level of resilience and majority of them (75.5%) had average level of total health-related quality of life. Conclusion: There is a negative correlation between the distress symptoms exhibited by the patient and their overall level of resilience, as supported by statistical analysis. Besides, a substantial negative correlation was recorded between the distress symptoms experienced by the patients and their overall health-related quality of life. Recommendations: designing and implementing intervention programs that improve patients' health-related quality of life since congestive heart failure affect their capacity for resilience.