Background: Heart Failure (HF) is a complex, fatal illness with high expenses, major morbidity and mortality, and poor capacity for function as well as quality of life. Aim: To evaluate the effect of implementing clinical nursing pathway on anxiety and satisfaction among heart failure patients at Cardiac Care Units. Design: A Quasi-experimental design was used. Setting: This study was conducted in Cardiac Care Units at Port Said Governorate affiliated to Egypt Healthcare Authority hospitals: El-Salam Hospital, Al-Hayat Hospital, El-Zohoer Hospital, and Al-Shifa Medical Complex Hospital. Subjects: A purposive sample of 145 heart failure patients was included. Tools of data collection: Three tools were used, heart failure patient assessment, heart failure patient anxiety level assessment, and heart failure patient satisfaction with the caring process. Results: There was a statistically significant difference (P=0.000**) between pre- and post-applying nursing pathway intervention related to the anxiety level of studied heart failure patients with a mean anxiety level of (63.51), and (37.95) respectively. and there was a significant difference (P=0.000**) between pre- and post-applying nursing pathway intervention regarding the satisfaction level of studied heart failure patients with a total mean (of 2.85), (3.69) respectively. Conclusion: Applying the clinical nursing pathway improved the anxiety and satisfaction levels of heart failure patients. Recommendations: Application of a multidisciplinary clinical nursing pathway intervention for patients with heart failure was recommended, rather than traditional care.