Background: Good career adaptability is extremely important for nursing students' future job choice and development, especially for interns at the crucial phase of career development. The propensity of nursing interns to change careers is influenced by a variety of elements, including personality traits and entrepreneurship tendencies. Aim: Explore the relation between personality traits and entrepreneurship tendencies with career adaptability among nursing interns. Subjects and Method: Design:  Correlational descriptive design .Setting: Faculty of Nursing, Port-Said University. Subjects consisted of all nurse interns 120. Tools: Three used for data collection involved of; Personality traits scale, entrepreneurial culture awareness scale and career adapt-abilities scale. Results:49.2% of nurse interns had poor availability of overall personality traits. Whereas, 73.3% of them had high entrepreneurship knowledge, 59.8% had high entrepreneurial attitudes, and 62.5% perceived high level obstacles to entrepreneurship. While, 81.7% of them had high level of overall career adaptability. Conclusion: positive correlation was found between personality traits and entrepreneurial culture awareness and career adaptability. Also, there is a positive correlation between entrepreneurial culture awareness and career adaptability. Recommendations: Faculty administration should create professional career counseling unit to help students improve entrepreneurship tendencies and career adaptability.