Background: Pediatric epilepsy is one of the most common neurological disease worldwide. In Egypt the epilepsy prevalence in children was reported as (9/1000). Parents, especially mothers, have essential roles in assisting their epileptic children in manage their condition and deal with psychological issues. Aim: The present study aims to; assess of maternal practices on quality of life for their epileptic children. Subjects and Methods: Design, A descriptive cross sectional research design was used to conduct the study at El-Arab health unit in Port Said city. Subjects: A purposive sample of 80 mothers and their epileptic children was included in the study. Children's age ranged from 6-12 years. Tools Three tools used for collecting data consisted of; (1) A structured interviewing sheet include personal characteristics of epileptic children and their mothers, and medical history, (2) Mothers practices questionnaire sheet, (3) Quality of life (QOL) sheet. Results: the current study revealed that about three quarters of the studied mothers (73.8%) had inadequate practice score, about two thirds of the studied children (62.5%) had inadequate QOL scores. Conclusion: the most of the studied mothers had poor practices which negatively effects on their children quality of life. Recommendations: provide supportive educational interventions to support epileptic child and his/her family in all quality life domains and disease management process, increase awareness of epileptic children's mothers and care givers about care practices regarding epilepsy and existing resources in Egypt, and develop patient education sessions through mass media to reduce exposure to seizure triggers.