Background: The epilepsy plays major problems around the world due to poor knowledge of the caregivers. There is a need for creation of awareness about the epilepsy among the caregivers. Aim: The present study aims to; study effect of maternal practices educational program on quality of life for their epileptic children. Subjects and Methods: A quasi-experimental research design was used to conduct the study at El-Arab health unit in Port Said city. A convenient sample of 80 mothers and their epileptic children was included in the study. Children's age ranged from 6-12 years.Tools Three tools were used for collecting data consisted of; (1) A­ structured interviewing sheet include personal characteristics of epileptic children and their mothers, and medical history, (2) Mothers practices questionnaire sheet, (3) Quality of life (QOL) sheet. Results: the current study revealed that the most of the studied mothers (80%) had adequate practice after implementation of the intervention, there was statistically significant difference between before and after implementation of the program with p-value whereas (P=0.000), and (63.7%) of the studied epileptic children had good quality of life after intervention. Conclusion: the educational intervention had a positive effect on the epileptic children's mothers' practices which improve their children quality of life. Recommendations: provide supportive educational interventions to support epileptic child and his/her family in all quality life domains and increase awareness of epileptic children's mothers and care givers about care practices regarding epilepsy and existing resources in Egypt.