Background: Post-traumatic stress disorder (PTSD) is a serious psychiatric disease that occurs after a traumatic experience, such as a cancer diagnosis. Hope is regarded as a significant factor impacting the experience and outcomes of cancer therapy. Aim: This study aimed to explore the relation between post-traumatic stress disorders and hope level among cancer patients. Subjects and Method:Desigh: A descriptive correlational research design was utilized. Subjects: The study subjects included 183 cancer patients; Setting; The study was carried out from the inpatients department at Sohag oncology center.Tools: Two tools were utilized to collect data which were; Post-Traumatic Stress Disorders Scale, and Herth Hope Index, In addition to personal and clinical data sheet. Results: More than two-thirds of the study participants(67.2%) had moderate PTSD, while more than half of cancer patients (54.1%) had moderate hope, according to the findings . Conclusion:  There was a highly statistically significant negative correlation between total PTSD score and total hope  score among the studied subjects. Recommendations: Develop and implement psychoeducational programs for cancer patients that teach stress management, meditation, and mindfulness-based therapies.