Background: Breast cancer is the most common invasive cancer in women, and the second main cause of cancer death among them, after lung cancer. Cancer -related pain often co-occurs with insomnia. Aim of study: Explore the effect of implemented acupressure on pain among breast cancer patients. Subjects and Method : Design: A quasi-experimental research design was used in this study. Setting:  The study was conducted in Oncology Department at Mansoura University Hospitals. Subjects: A purposive sample of 60 adult female patients with breast cancer. Tool of data collection:  The data collected through the following tools: Structured interview, Pain assessment tool and Numeric rating Scale of pain. The results: The study revealed that after implementing of acupressure, there was decreased in pain for study sample (t-test=5.34*) rather than the control sample. Conclusion: This study concluded that, implementing of acupressure have positive affect on reducing pain among breast cancer patients. Recommendations: Encourage oncology hospitals to apply acupressure as a treatment line to manage pain for breast cancer patients.  Also, further researches are needed with large sample size for generalization of the results.