Background: An important fitness issue that affects people of all racial and ethnic backgrounds is sleep disturbance. Cancer patients may experience sleep disturbances due to a variety of factors, including cancer treatment-related metabolic abnormalities. Sleep difficulties, such as difficulty getting asleep, difficulty staying asleep, poor sleep efficiency, early awakenings, and excessive daytime sleepiness are common in cancer patients. Aim of study: Evaluate the effect of implementing acupressure on quality of sleep among patients with breast cancer. Subjects and method: Design: A quasi-experimental research design was utilized in this study. Setting:  The study was applied in Oncology Department at Mansoura University Hospitals. Subjects: A purposive sample of 60 adult females' patients with breast cancer. Tool of data collection:  The data collected using the following tools: Structured interview and Sleep Scale. The results: The study found that once acupressure was applied, there was an improvement in the quality of sleep for the study pattern rather than the control group (p value =. 0.001). Conclusion: This study found that using acupressure improve sleep quality inpatients with breast cancer.  Recommendations: Encourage cancer treatment facilities to use acupressure as a therapeutic option to enhance sleep quality. In order to generalize the findings, additional studies with a high sample size are also required.