Background: Maternal newborn skin to skin contact (SSC), is a significant strategy for improving breastfeeding initiation, duration, and exclusivity during childbirth. Ensuring evidence based maternity policies that facilitate “no separation" is an essential responsibility for all birth attendants to ensure optimum level of health for mothers and their children. Aim: The study aimed to evaluate the effect of mother and newborn immediate SSC after delivery on maternal and newborn health. Study design: A quasi-experimental research design was used. Setting: This study was conducted at labor and delivery unit of Women Health Hospital in Port Said city. Sample: Purposive sampling technique was used to select 200 women (100 women for study group and 100 women for control group) during the study period (6 months). Tools: Three tools were used for collection of data, maternal assessment sheet, newborn assessment sheet and maternal satisfaction scale. Results: There is a highly positive statistically significant relationship between maternal and newborn immediate SSC regarding initiation of first breast feeding and its duration among studied women compared to control group at p ≤ 0.001. Most of studied group have highly maternal satisfaction compared with control group. Conclusion: Women who practice SSC have a shorter duration of placental expulsion, less blood loss, early initiation of first breast feeding and highly satisfaction compared to control women. Recommendation: It is necessary at the hospital managerial level, to enhance facilities for applying SSC through department protocols and scientific guidelines, posters, and written instructions in the delivery room and to be included in policy and procedures.