Background: Dementia is a progressive neurodegenerative condition characterized by altering cognitive processes, behavior, and emotional state. It limits the ability to develop daily life activities. Aim: To explore the effects of psycho-educational program alone and combined with reminiscence therapy on depression, cognitive and non-cognitive behaviors among patients with dementia. Subjects and Methods: Design: A quasi-experimental study was utilized. Setting: The study was conducted at the outpatient department at Psychiatric and Mental Health Hospital in Meet-khalf in Menoufia, Egypt, from the beginning of November 2021 to the end of June 2022. Subjects: A purposive sample of sixty patients was classified into two groups, thirty patients in psychoeducational program group and thirty patients in psychoeducational program combined with reminiscence therapy group. Tools: Personal characteristics sheet, Cornell scale for depression in dementia (A-CSDD) and the Alzheimer's disease assessment scale (ADAS). The Results: The study revealed that patients on the psychoeducational combined with reminiscence therapy had a higher decrease in total mean scores in the A-CSDD (67.16 before, 48.73 after, and 50.26 follow-up) and ADAS (25.03 before, 14.43 after, and 17.80 follow-up) than patients on the psycho-educational program alone. The difference between the two groups' post-test intervention scores was statistically significant (p≤0.000). Conclusion: Psycho-educational program combined with reminiscence therapy was more effective in alleviating depression, and improving cognitive and non-cognitive behaviors among patients with dementia than psycho-educational program alone. Recommendations: A comprehensive treatment plan involving a combination of reminiscence therapy and psychoeducational program should begin with dynamic caregivers at an early stage of dementia.