Background: Nursing errors constitute the largest cause of mortality worldwide. Error reporting is critical for lowering the number of errors and enhancing patient safety. By understanding the circumstances of the error, changes to prevent similar errors from occurring can be introduced. Aim: The aim of this study was to identify the obstacles of reporting nursing practice errors in Port Said Governmental Hospitals. Setting: The research was carried out at all four government hospitals in Port Said that are linked with the Ministry of Health. Design: The current study employed a descriptive research approach. Sample: A total of 265 nurses from all hospitals were included in the study. Study tools: Obstacles of reporting nursing practice errors questionnaire. Result: Individual obstacles were 50.3±12.34, while, the Burden of Effort obstacles dimension was 13.86±3.78. Nurses should always be encouraged to report nursing practice errors" was the highest strategy used to improve the reporting of nursing practice errors 4.49±0.67, while the lowest strategy was “Reporting errors shouldn't be used against reporters" 3.74±0.94. Conclusion: Cultural & Information gap obstacles dimension was the highest mean percent score dimension of obstacles. While Individual obstacle was the lowest-ranked obstacle for reporting nursing practice errors. Recommendations: establish a clear guidelines and procedures for reporting errors and providing regular feedback regarding nurses performance and also related to reported errors.