Background: The terms "stroke" and "nontraumatic cerebral hemorrhage" are used interchangeably. The ratio of infarct to bleeding varies by demographic (race, age, comorbidities), but it is roughly 4 to 1. A variety of disease mechanisms can cause a cerebral infarction, but they all result in obstruction of cerebral arteries or veins. Aim of the study: Explore effect of an educational program on nurses' practice regarding care of patients with cerebral stroke. Subjects and method: Design: A quasi-experimental design was utilized to conduct the study in the intensive care unit at Port Said general hospitals. Setting: The study was conducted in the intensive care unit at Port Said General Hospital. Subjects: convenient sample (50) nurse. Tools: Nurses' observational checklist. The Results: (20%)of studied nurses had satisfactory total practice preprogram compared to (96%) immediately after post-program implementation and (92%) of them followed up 3months after program implementation.  Conclusion: Statistically significant differences in nurse practice before, immediately, and after program implementation. Recommendations: Provides a continuous training program for nurses in the care of stroke patients, as well as hands-on training in low-practice areas to provide the highest level of care for nurses.