Obesity increases the risk of several debilitating, and deadly diseases, including diabetes, heart disease, and some cancers. Pharmacological therapy of obesity is costly and associated with multiple side effects led to patient non-compliance. In this study, an alternative natural remedy through the use of three vegetable parts by-products of food processing (orange peel, eggplant peel, and tomato pomace) was applied in a dietary intervention to improve the complications of obesity in rats. Rats (n=36 rats) were divided into two main groups, the first group (Group 1, 6 rats) still fed on basal diet as a normal and the other main group (30 rats) was feed with diet-induced obesity (DIO) for 8 weeks which classified into five sub groups as follow: group (2), fed on diet-induced obesity (DIO) as a positive control; groups (3,4,5 and 6), fed on DIO containing plus 7.5% OPP, EPP, TPP and Mix (OPP+ EPP + TPP by equal parts), respectively. At the end of the experiment (8 weeks), rats of the normal group recorded increasing on body weight rate by 75.82% from the starting point of the experiment while obese group was 116.40%. Dietary intervention with OPP, TPP, EPP and their mixture on the diet by 7.5% induced significant decreasing on body weight of the obese rats by the rate of 99.13, 98.20, 87.10 and 82.80% from the starting point, respectively. Also, dietary intervention with OPP, TPP, EPP and their mixture induced significant ameliorative effect in different complications induced by obesity including increase the plasma non-enzymes antioxidant (GSH, and GSSG), improve the liver functions and serum lipid profile, and decrease the blood glucose level and  TBARS (biological indicator of lipid oxidation). The highest ameliorative effects was recorded for the Mix followed by EPP, TPP and OPP, respectively. In conclusion, the present data support the benefits of dietary modification, including bioactive compounds supplementation, in alleviating some complications associated obesity.