The present study aims to investigate the effectiveness of three food processing by-products extracts including eggplant peel extract (EPP), onion skin extract (OSE), pomegranate peel extract (PPE) and their mixture in modulating the hyperglycemia using alloxane-induced diabetic rat model. Also, the effect of these extracts on diabetic complications including liver functions, serum lipid profile and antioxidant enzymes, the biomarkers of defense system in RBC's were also investigated. Treatment of rats with alloxan caused a significant (p≤ 0.05) increased in serum glucose level by the ratio 163.33% compared to normal control group. Phyto-extracts (EPE, OSE, PPE and their mixture, 150 mg/kg bw/day), lead to decrease this elevation value and recorded 71.17, 53.25, 57.17 and 47.30%, respectively, compared to normal control group. The maximum hypoglycemic yield was noticed for the extracts mixture treatment when compared with the rest of tested extracts individually. Also, phyto-extracts treatments attenuate the different diabetic complications including liver functions and serum lipid profile. The same treatment improve the antioxidant defense system in RBCs through elevation the activities of antioxidant enzymes (glutathione peroxidase, superoxide dismutase and catalase).   In conclusion, the present study has demonstrated multiple beneficial effects of EPP, OSE and PPE in combating diabetes and diabetes-related complications. Thus, we recommended such phyto- extracts to be included in our daily diets, drinks, food supplementation and pharmacological formulae.