Lead is a natural occurring element that have a high atomic weight and is wide distributed in the environment, with a high degree of toxicity that affect health. This study investigated the effect of mixtures of propolis and albumin in renal hepatotoxicity by lead (Pb) in rats.

Lead toxicity was evaluated in rats, after one dose of 0.5 mg (Pb) last 12 days. 25 female albino rats were used, average weight 180±10 grm, divided to 5 groups each of 5 mature rats, the first group control(g1) infected group with 0.5 mg lead(g2), group (3) fed a stable food +0.5 mg (Pb) +150mg/kg propolis+5mg albumin, group (4) fed stable food +0.5mg (Pb)+200mg/kg propolis + 5mg albumin, group (5) fed stable food +0.5mg (Pb) +300mg/kg propolis+5mg albumin Mixure treatment for 5 weeks .

Blood picture, renal and liver function,antioxidant , glutathione peroxidase, albumin and FSH were investigated. The obtained results confirm the values of the propolis and albumin mixtures as hematinic potentials, improve hepato-renal functions, elevate antioxidant and while mixtures reducedFSH. It is concluded that propolis and albumin may improve health problems, confirm hematinic potential, hepato-renal function, immunity