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Evaluating the bioactive compounds content, toxicological aspects and antibacterial/antifungal activities of the reishi mushroom (Ganoderma lucidum) ethanol extract

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Last updated: 24 Dec 2024

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Abstract

 Reishi mushroom (Ganoderma lucidum, family Ganodermaceae) is spread
worldwide and is widely used for several nutritional and medical purposes. Therefore,
knowledge of all aspects of this mushroom's composition, toxicity and biological activities is
required. The present study aims to determine the bioactive compound content, toxicity
studies, and antibacterial/antifungal activities of Ganoderma lucidum ethanol extract (GLEE). Data on the nutrients composition of Ganoderma lucidum powder indicated that crude
fiber and carbohydrates were the largest compounds (51.06 ± 2.42 and 36.17 ± 3.91%,
respectively), followed by total protein (8.69 ± 0.69 %), ash (2.21 ± 0.14%) and crude fat
(1.87 ± 0.20%.). Also, Furthermore, the nutraceuticals (bioactive compounds) content of GLEE indicated that terpenoids were the largest compound (241.47± 20.72 mg linalol.100 g-1)
followed by polysaccharides (154.30± 19.06 mg starch equivalent.100 g-1), phenolics (49.98 ±
5.61 mg gallic acid equivalent.100g-1), triterpenoids (51.16 ± 6.49 mg ursolic acid.100 g-1).
Furthermore, GL-EE recorded antibacterial and antifungal. On the other side, the toxicity
studies of GL-EE were evaluated in Albino rats using standard methods. Various doses (2000
and 5000 mg/kg) of the extract were orally administered to rats and kept under close
observation for the next 10 days. Data from the acute toxicity study did not show any toxicity
signs and symptoms at doses 2000 mg/kg and 5000 mg/kg of GL-EE. Such signs and
symptoms, including no morbidity or mortality, were observed. As a result, the LD50 of the
Gl-EE could be greater than 5000mg/kg body weight. The effective biotransformation and
elimination of this natural product within a short period. Therefore, the present study
recommended that Ganoderma lucidum extract (GL-EE) could be used safely in different
nutritional and medical applications.

DOI

10.21608/pssrj.2023.184359.1217

Keywords

Chemical composition, bioactive compounds, Acute toxicity, body weight, organs weight

Authors

First Name

أسماء

Last Name

ربيع علي

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-

Affiliation

جامعه بورسعيد كلية التربية النوعية

Email

asmarabee44@gmail.com

City

-

Orcid

-

First Name

عبير السيد حسن

Last Name

الخميسى

MiddleName

-

Affiliation

قسم الاقتصاد المنزلي - کلية التربية النوعية جامعة بورسعيد - بور سعيد - مصر

Email

abeer.elkhamisy@yahoo.com

City

بورسعید ، مصر

Orcid

-

First Name

يوسف عبد العزيز

Last Name

الحسانين

MiddleName

-

Affiliation

کلية الاقتصاد المنزلى - جامعة المنوفية

Email

yousif12@hotmail.com

City

شبین الکوم

Orcid

1111-1111-1111-1111

First Name

نجلاء

Last Name

فتحي

MiddleName

-

Affiliation

جامعه بورسعيد كليه تربيه نوعيه اقتصاد منزلي

Email

drnagla.foodanalysis@gmail.com

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-

Orcid

-

Volume

20

Article Issue

20

Related Issue

44563

Issue Date

2023-04-01

Receive Date

2022-12-30

Publish Date

2023-04-01

Print ISSN

2536-9253

Online ISSN

2682-325X

Link

https://pssrj.journals.ekb.eg/article_327801.html

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https://pssrj.journals.ekb.eg/service?article_code=327801

Order

13

Type

المقالة الأصلية

Type Code

864

Publication Type

Journal

Publication Title

مجلة کلية التربية النوعية - جامعة بورسعيد

Publication Link

https://pssrj.journals.ekb.eg/

MainTitle

Evaluating the bioactive compounds content, toxicological aspects and antibacterial/antifungal activities of the reishi mushroom (Ganoderma lucidum) ethanol extract

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Article

Created At

24 Dec 2024