Pharmaceutical industry is one of the most sensitive industries related to human health and safety. Many Pharmacies today faced a critical problem of large stocks of medicines that are past their expiry dates. In low-income countries like Egypt, many such stagnant medicines are the result of low sales for their specific items due to incorrect planning of quantities ordered. If not adequately monitored or regulated, expired pharmaceuticals may be repackaged and sold as counterfeits or be dumped without any thought of the potential environmental damage which contradicts with the requirements of the world to move towards sustainability. This study aimed to identify the effect of digitalization on the pharmaceutical supply chain sustainability by applying on the reverse logistics of pharmacies in the city of Aswan, and reducing the volume of stagnant medicine in pharmacies that eventually becomes expired and requires disposal, which negatively affects the environment. The researcher used the descriptive analysis approach, a survey was designed and distributed to a sample of (300). The study reached many results, the most important that There is a statistically significant effect between the dimensions of digitalization (Administrative requirement, Tools & Equipment, Software and Network) and Pharmaceutical supply chain sustainability.