The quickest methods for battling the new coronavirus pandemic at the beginning of the COVID-19 outbreak were therapeutic treatments based on approved drugs. Although there are now many vaccines available, it will take time for the global vaccination program to take effect. Therefore, in addition to vaccination, repurposing currently available antiviral, antibiotic, and other types of medications has been suggested as a complementary medical strategy for COVID-
19 infections. Analytical methods for assessing drug concentrations in biological fluids and pharmaceutical products are necessary due to the drugs' extensive clinical potential as well as their potential side effects. The following article was introduced by presenting a mini-review of the different methods used for the quantitative determination of these drugs in order to encourage and facilitate collecting literature review for other researchers who will have studies related to the presented compounds. The review discussed techniques used for the determination of each drug quantitatively involving spectrophotometric (UV and visible), spectrofluorimetric, electrochemical and chromatographic (TLC and HPLC) methods either in a biological sample or in the pharmaceutical dosage forms. All methods included in the review are validated and constructed according to ICH guidelines.