Genus Zamia is a diverse group of cycads belonging to family Zamiaceae which includes most cycads. It is ranked as the second-largest genus of extant cycads in the new world. In contrast to other cycad species, Zamia species are trunkless, deciduous shrubs. The genus Zamia is by far the most ecologically varied, widely dispersed, and species-rich genus in the Americas. They are dioecious plants with male and female reproductive cones. Zamia plants is considered rich sources for numerous different natural metabolites which may contribute to various biological activities such as cytotoxic, antimicrobial, antioxidant, and anti-inflammatory activities. These metabolites include flavonoids, biflavonoids, phenolic acids, volatile oils and lignans which are considered the significant components of the phytochemical profile of Zamia. Zamia is a popular ornamental plant. It is also acknowledged as a therapeutic herb in both conventional and western medicine. Various Zamia species have traditionally been used to treat a range of ailments by elderly locals in various locations. These ethnobotanical uses have led researchers to discover some valuable pharmacological properties of some Zamia species like cytotoxic, antiprotozoal, antioxidant, antimicrobial and anti-Alzheimer activities. In this review, We have given an overview of different phytochemicals types present in Zamia species and their reported bioactivities in addition, the pharmacological, ethnobotanical properties of certain Zamia species.