ABSTRACT
Objectives: This study was carried out to identify the antimicrobial peptides histatin as biomarkers for caries risk assessment in children. Subjects and methods: This study was conducted on thirty three patients with different caries risk assessment. All the patients were divided randomly in to three equal groups according to the American Dental association caries risk assessment form as the follow; the first group; Children with low caries risk assessment (Control Group), the second group; Children with moderate caries risk assessment, the third group; Children with high caries risk assessment. Results: The results of this study revealed that; in comparison between the three groups according levels of Histatin, results showed significant increased in histatin levels in high risk group and moderate risk group in comparison with low risk group. Conclusion: Based on the results of this study, antimicrobial peptides histatin may be used as good biomarkers for high caries risk patients.