Objective: This study was performed for comparative evaluation of the Giomer coating material versus Icon resin infiltration in masking White Spot Lesions (WSLs). Materials and methods: In this study, twenty patients were involved. Each patient had at least two WSLs in their anterior teeth (total 40 WSLs). The WSLs were divided into two equal groups randomly, control group (Icon), and intervention group (Giomer coating material). According to the instructions provided by the manufacturers, all materials were applied. The WSLs color change (ΔE) was assessed by Vita Easyshade V device at the following evaluation periods: T0: before the application of the materials, T1: immediately following treatments, T2: three months later, T3: six months later, and T4: one year later. Data were recorded and statistically analyzed. Results: The statistical analysis of each group showed that after immediate application, the ΔE for each group significantly improved. However, the ΔE of all groups significantly dropped over the time. The Icon group showed significant improvement in ΔE more than Giomer group. Conclusions: Icon resin infiltration technique is superior to Giomer in esthetics improvement. Giomer can be used for a short time as a prevention protocol and control of caries progression.