Purpose: to evaluate the effect of EDTA, Q-Mix, Chitosan, and NaOCl on Biodentine bond strength.
Materials and Methods: Forty extracted human premolars with type I root canal system were used in this study. After crown removal and working length determination, all root canals were prepared using a ProTaper NEXT Nickel Titanium rotary system up to X4 apical size corresponding to X4. The specimens were then randomly divided based on the final irrigation regimen into 4 groups (n = 10): Group 1: 17% EDTA, Group 2: Q-Mix, Group 3: 0.2% Chitosan, and Group 4: NaOCl. All samples were obturated using Biodentine as a filling material. Each sample was sectioned horizontally to produce a 2 mm thick disc per specimen. A universal testing machine was used to evaluate the push-out bond strength.
Statistical Analysis: Data were analyzed using one-way ANOVA followed by pairwise comparison using the Tukey method. The statistical level of significance was set at 0.05.
Results: 17% EDTA showed the highest push-out bond strength followed by Q-Mix> 0.2% Chitosan >NAOCl.
Conclusion: Different irrigants used during the Final irrigation of the root canal impact biodentine bond strength.