ABSTRACT
Objectives: the present study aims to evaluate and compare the antimicrobial efficacy of irrigant solutions with different natures against E. faecalis. subjects and methods: A total of 48 contaminated roots were randomly divided into four groups (n = 12) according to the irrigation regimen used as follow: Group I: A 80% Aloe Vera extract irrigant solution. Group II: A 3% Nanosilver irrigant solution. Group III: A 2% Chlorhexidine irrigant solution. Group IV: A 1 % Sodium hypochlorite irrigant solution. The microbial counts were assessed by CFU/ml. Results: a significant reduction in the CFU count results of E. faecalis after irrigation in all studied groups. NaOCl had the highest antimicrobial effectiveness against E. faecalis and showed significant differences compared with CHX, Aloe Vera, and AgNPs solutions. Conclusion: significant antimicrobial effect against E. faecalis. The use of NaOCl as an irrigant solution had a higher and significant antimicrobial effect against E. faecalis than CHX than AgNPs than Aloe Vera.