Objectives: The aim of the study is to evaluate the effectiveness of titanium prepared platelet rich fibrin (TPRF) for treatment of gingival recession and comparing it to platelet rich fibrin (PRF).

Material and methods: This study was conducted on subjects having multiple gingival recession. Twenty-four patients of both sexes, aged between (23-41) and having miller class I, II were selected to participate in the present study. Subjects were randomly divided into two equal groups with coin toss method. The plaque index, gingival index, Periodontal pocket depth, Recession width, Recession depth, Clinical attachment level, Keratinized tissue width, keratinized gingival mucosa, Gingival thickness, T-TRF membrane thickness, and VAS were measured.

Results: At 6 and 9 months: there was a statistically significant difference in mean RD in the two groups. T. PRF group showed a less mean RD, RW, and KTW than PRF group. At 9 months: T. PRF group showed a significant higher mean GT than PRF group. At day 3 and 7: T. PRF group showed a significant lower mean VAS than PRF group.

Conclusion: In conclusion Within the limits of this study, the results demonstrated that T-PRF procedure is a safe, effective method in treating gingival recessions. In addition, this procedure can be recommended to treat localized or multiple-adjacent gingival recessions without additional surgery. However, future randomized clinical trials with a split-mouth design and larger sample size are essential for evaluating the TPRF efficiency in gingival recession treatment modalities.