Purpose: The purpose of the current study was to evaluate the fracture resistance of pulpotomized primary molars restored using hybrid ceramics endocrowns and prefabricated zirconia crowns. Materials and methods: Eight freshly extracted human mandibular second primary molars underwent pulpotomy procedure. Teeth were randomly divided into two groups according to the type of coronal restoration: Endocrown (EC) group (n=4) restorations made of CAD/CAM Milled Hybrid Ceramic blocks (VITA ENAMIC), and Zirconia crown (ZC) group (n=4) restored by prefabricated zirconia crowns (Nu Smile). A universal testing machine was used to evaluate fracture resistance of tested specimens. Results: There was no statistically significant difference (P=0.074) in the mean fracture resistance for EC group (1968.6±985.4) compared to the mean fracture resistance for the ZC group (890.9±142.5). Conclusion: Endocrowns can be used as a treatment option in pulpotomized primary molar teeth. VITA ENAMIC endocrowns can withstand the maximum intraoral masticatory force in the primary molars.