A field experiment was conducted in sandy soil under New EL-Salheya conditions, Egypt, to investigate the effect of yeast industrial waste (YIW) and farmyard manure (FYM) both of them alone and combination at 3 different mixtures from studied soil amendments as well as control (without soil amendments) to enhance some chemical and physical properties of sandy soil and corn grain yield. The results demonstrated that soil pH, ECe, Bd, PR, and HC decreased by increasing application of YIW and FYM both of them alone and 3 different mixtures, while the OC, available NPK and MWHC were increased. Also, the results demonstrated that the application treatments of the YIW and FYM increased the corn grain yield. The average increases of corn grain yield were 64.77, 116.73, 182.21, 147.69 and 89.32% with the application treatments of YIW and FYM at T2, T3, T4, T5 and T6, respectively, relative to control. The more effective treatment caused highly increased in corn grain yield was applied mixture treatment of 20 m³ ha^-1 YIW+20 Mg ha^-1 FYM (T4). So, we can say that the application mixtures from YIW and FYM are considered effective in improvement sandy soil properties and productivity, which reduces environmental pollution from those wastes in the event that they are not used as a soil conditioner.