One of the most important management which influencing the welfare of chickens is color of light. Therefore, the objective of this study was to determine how different light colors affected the immune profile, meat chemical composition, and carcass features of grill chickens. A total number of 504 one-day-old Indian River (IR) broilers were exposed to white light (WL), green light (GL), blue light (BL) and Mix (GL X BL), respectively, by using a light-emitting diode system for 5 wk. Each color group was further divided into three housing systems sand (S), wood shavings (WSH) and cages (C)). There were three replicate for each light treatment and housing system, 14 birds per replicate. The effects of monochromatic light and litter type on carcass traits, meat composition and immune response were studied. The results obtained indicated that broiler chicks exposed to white light (WL) and reared on sand litter type recorded the highest absolute and relative weights of carcass, giblets and total edible parts compared with those in WL, BL, MIX, respectively. The interactions between GL with cages showed significantly the lowest averages of plasma AST, ALT, uric acid and creatinine compared with other groups. Broiler chickens exposed to GL and BL showed significantly increased plasma GP_X, IgG and IgM and significant decreased plasma MDA when compared with different lighting color. These results suggest that GL and BL with cage housing system enhance the antioxidant status and immunity response than WL and MIX colors in broiler chicks.