ABSTRACT
Background: Hepatocellular carcinoma is the third most common cancer to be fatal (HCC). Binding to the transmembrane receptor Patched 1 (PTCH1) depresses the transmembrane G protein-coupled receptor Smoothened (SMO), hence initiating the hedgehog (HH) signaling pathway. This investigation looked at the potential therapeutic and preventive benefits of cannabidiol oil in adult rats that had been subjected to diethyl nitrosamine (DENA)-induced HCC.
Materials and methodology: Of the fifty rats, five groups of ten male rats each were formed. Group I: The group for references. Group II got DENA IP injections for a duration of 12 weeks. For a duration of 12 weeks, rats in Group III received DENA injections in addition to oral CBD provided every other day at a rate of 0.5 ml/kg body weight. Group IV rats were administered oral CBD every other day for two weeks prior to getting a DENA injection for a duration of 12 weeks. After their prior DENA injection, rats in Group V received oral CBD every other day for two weeks.
An examination of the histology of liver tissue was performed.
In conclusion, the treatment of CBD resulted in a considerable improvement in the histopathological liver tissues of adult male rats with DENA-induced HCC.