The current investigation looked at how changes in serum glucose and liver enzymes in rats given a high-calorie diet (HCD) to make them fat were affected by a methanolic extract of P. harmala/ nanopartical (H/ZnONP) extract. Half of the rats became obese after being given HCD for a month. The 36 male rats were split into two groups (normal and obese), each of which had three subgroups.For a month, the main group received H/ZnONP 200 and 400 mg/kg BW/day orally, while the control group of people continued to be overweight and normal. Blood was drawn and tested at a lab for glucose levels and liver enzymes after 4 weeks of treatment. The collected results showed that giving obese rats H/ZnONP considerably reduced serum glucose levels as well as ALT and AST enzymes. According to the data, supplementing rats with H/ZnONP has a powerful anti-obesity effect via elevating glucose levels, especially at high doses.
From the data, we may infer that high-dose H/ZnONP supplementation has effective anti-obesity effects in rats through enhancing glucose levels and liver function.
Keywords: Obesity; Methanolic extract of P. harmala / ZnO nanoparticles