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352653

Validated Spectrophotometric Methods Based on Charge Transfer Complexation Reactions for the Quantification of Antimalarial Drug: Chloroquine Phosphate in Pure and Dosage Forms

Article

Last updated: 24 Dec 2024

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Subjects

-

Tags

Basic and applied research of Chemistry,

Abstract

Chloroquine phosphate (CQP), an antimalarial medication, has been determined using two straightforward, sensitive, quick, and verified spectrophotometric techniques. The procedures were based on the generation of charge transfer complexes in methanol utilizing alizarin red S (ARS) and quinalizarin (Quinz) as chromogenic reagents, respectively, with absorption maxima at 560 and 531 nm for each. Investigated was the optimization of the reaction conditions, including the kind of solvent, reagent concentration, and reaction time. Beer's law is effectively observed using Quinz and ARS, respectively, in the concentration ranges of 1.0-20 and 1.0-16 g mL-1, with strong correlation coefficients (r2 ≥0.9995) and low relative standard deviations (RSD%≤ 1.07). Calculations were also made for the molar absorptivity, Sandell sensitivity, detection, and quantification limitations. The approaches were successfully used to identify CQP in pharmaceutical formulations, and the standard addition technique. was used to evaluate the methods' validity. Results from the suggested procedures for pure CQP and dosage forms were in good agreement with those from the previously described approach.

DOI

10.21608/bfszu.2023.235670.1308

Keywords

chloroquine Phosphate, Spectrophotometry, Charge transfer reaction, dosage forms, method validation

Authors

First Name

Ayman

Last Name

Gouda

MiddleName

A

Affiliation

Chemistry Department, Faculty of Science, Zagazig University, Zagazig, Egypt

Email

aymangouda77@gmail.com

City

Zagazig

Orcid

-

First Name

Ragaa

Last Name

elsheikh

MiddleName

-

Affiliation

Chemistry Department, Faculty of Science, Zagazig University, Zagazig, 44519, Egypt.

Email

ragaaelsheikh@hotmail.com

City

-

Orcid

-

First Name

Sara

Last Name

Gaber

MiddleName

-

Affiliation

Chemistry Department, Faculty of Science, Zagazig University, Zagazig, 44519, Egypt.

Email

moradqwer81@gmail.com

City

-

Orcid

-

First Name

Moataz

Last Name

Mahmoud

MiddleName

S.

Affiliation

Chemistry Department, Faculty of Science, Zagazig University, Zagazig, 44519, Egypt.

Email

mezooom53@gmail.com

City

Zagazig

Orcid

-

First Name

Ahmed

Last Name

Abdel Allem

MiddleName

F

Affiliation

Chemistry Department, Faculty of Science, Zagazig University, Zagazig, 44519, Egypt.

Email

af2401024@gmail.com

City

-

Orcid

-

First Name

Ahmed

Last Name

El Sayed

MiddleName

-

Affiliation

Chemistry Department, Faculty of Science, Zagazig University, Zagazig, 44519, Egypt.

Email

a7medzekei@gmail.com

City

-

Orcid

-

First Name

Ahmed

Last Name

Ghazy

MiddleName

-

Affiliation

Chemistry Department, Faculty of Science, Zagazig University, Zagazig, 44519, Egypt.

Email

dr.ahm.ghazy@gmail.com

City

-

Orcid

-

Volume

2024

Article Issue

1

Related Issue

47419

Issue Date

2024-04-01

Receive Date

2023-09-11

Publish Date

2024-04-01

Page Start

182

Page End

194

Print ISSN

1110-1555

Article File

BFSZU_Volume 2024_Issue 1_Pages 182-194.pdf

PDF . 889.8kB

Link

https://bfszu.journals.ekb.eg/article_352653.html

Detail API

https://bfszu.journals.ekb.eg/service?article_code=352653

Order

19

Type

Original Article

Type Code

838

Publication Type

Journal

Publication Title

Bulletin of Faculty of Science, Zagazig University

Publication Link

https://bfszu.journals.ekb.eg/

MainTitle

Validated Spectrophotometric Methods Based on Charge Transfer Complexation Reactions for the Quantification of Antimalarial Drug: Chloroquine Phosphate in Pure and Dosage Forms

Details

Type

Article

Created At

24 Dec 2024