ManageChatDiscover
337051

Utilization of charge transfer complexation reaction for the spectrophotometric determination of acyclovir as antiviral drug in pharmaceutical formulations

Article

Last updated: 04 Jan 2025

OverviewSimilar Items

Subjects

-

Tags

Basic and applied research of Chemistry,

Abstract

The present work aims to develop and validate two simple, sensitive, accurate, precise and economical spectrophotometric methods for the determination of acyclovir (ACV) in pure form and pharmaceutical formulations. The developed methods are based on the formation of charge transfer complex between VAL as n-electron donor and quinalizarin (Quinz) or alizarin red S (ARS) as π-acceptor in methanol to form highly colored chromogens which showed an absorption maximum at 560 and 538 nm using Quinz and ARS, respectively. The optimization of the reaction conditions such as the type of solvent, reagent concentration and reaction time were investigated. Under the optimum conditions, Beer's law is obeyed in the concentration ranges 1.0–20 and 1.0–24 μg/ml using Quinz and ARS, respectively with good correlation coefficient (r2 ≥ 0.9994) and with a relative standard deviation (RSD% ≤ 0.80). The limits of detection and quantification were found to be 0.30 and 1.0 µg/ml for Quinz and 0.29 and 0.97 µg/mL for ARS. The methods were successfully applied to the determination of VAL in its pharmaceutical formulations and the validity assesses by applying the standard addition technique. Results obtained by the proposed methods for the pure VAL and commercial tablets agreed well with those obtained by the reported method.

DOI

10.21608/bfszu.2023.200069.1264

Keywords

Acyclovir, Spectrophotometry, Quinalizarin, Alizarin red S, Pharmaceutical formulations

Authors

First Name

Ayman

Last Name

Gouda

MiddleName

A

Affiliation

Chemistry Department, Faculty of Science, Zagazig University, Zagazig, Egypt

Email

aymangouda77@gmail.com

City

Zagazig

Orcid

-

First Name

Ragaa

Last Name

elsheikh

MiddleName

-

Affiliation

Chemistry Department, Faculty of Science, Zagazig University, Zagazig, 44519, Egypt.

Email

ragaaelsheikh@hotmail.com

City

-

Orcid

-

First Name

Moataz

Last Name

Mahmoud

MiddleName

S.

Affiliation

Chemistry Department, Faculty of Science, Zagazig University, Zagazig, 44519, Egypt.

Email

mezooom53@gmail.com

City

Zagazig

Orcid

-

First Name

Ghada

Last Name

Abdel Fattah

MiddleName

M.

Affiliation

Chemistry Department, Faculty of Science, Zagazig University, Zagazig, 44519, Egypt.

Email

www.bird9_1990@yahoo.com

City

Zagazig

Orcid

-

First Name

Alyaa

Last Name

Ibrahim

MiddleName

S.

Affiliation

Chemistry Department, Faculty of Science, Zagazig University, Zagazig, 44519, Egypt.

Email

alyaafares16@gmail.com

City

-

Orcid

-

First Name

Ahmed

Last Name

Abdel Allem

MiddleName

F

Affiliation

Chemistry Department, Faculty of Science, Zagazig University, Zagazig, 44519, Egypt.

Email

af2401024@gmail.com

City

-

Orcid

-

First Name

Nessma

Last Name

Jumaa

MiddleName

M.

Affiliation

Chemistry Department, Faculty of Science, Zagazig University, Zagazig, 44519, Egypt.

Email

nessmagomaa521@gmail.com

City

-

Orcid

-

First Name

Ahmed

Last Name

El Sayed

MiddleName

-

Affiliation

Department of Chemistry, Faculty of Science, Zagazig University, Zagazig, Egypt

Email

aymanchimca@yahoo.com

City

-

Orcid

-

Volume

2023

Article Issue

4

Related Issue

38871

Issue Date

2024-01-01

Receive Date

2023-03-14

Publish Date

2024-01-01

Page Start

55

Page End

65

Print ISSN

1110-1555

Article File

BFSZU_Volume 2023_Issue 4_Pages 55-65.pdf

PDF . 1.3MB

Link

https://bfszu.journals.ekb.eg/article_337051.html

Detail API

https://bfszu.journals.ekb.eg/service?article_code=337051

Order

5

Type

Original Article

Type Code

838

Publication Type

Journal

Publication Title

Bulletin of Faculty of Science, Zagazig University

Publication Link

https://bfszu.journals.ekb.eg/

MainTitle

Utilization of charge transfer complexation reaction for the spectrophotometric determination of acyclovir as antiviral drug in pharmaceutical formulations

Details

Type

Article

Created At

24 Dec 2024