Theba pisana is considered one of the most prevalent and dangerous land snails in the Mediterranean region especially in Egypt. Owing to their small sizes, climbing tendency, capability of producing hazardous effects on plants and, high reproductive rates, all these make difficulties of their effective control. The goal of the current study was to control this harmful snail by applying The Ovunhipita contraceptive pills. Three different concentrations of the drug (0.75, 1.5, and 3 µg/g) were tested on the reproductive biology, antioxidant enzymes and the histological structures of both hermaphroditic and digestive glands after 6 weeks of treatments using baits technique. Results indicated that egg masses laid / snail were decreased significantly (0.25, 0.15, and 0.15 egg mass/snail) after treatment with 0.75, 1.5 and 3 µg/g, respectively compared to control (1.65 egg mass/snail). Egg numbers /mass were significantly reduced to 56, 53, and 15.9 eggs/mass respectively compared to control (91.12 eggs/ mass). In addition, the number of eggs laid by snails, the rate of hatchability was significantly decreased with increasing concentration of the drug. The tested antioxidant enzymes (CAT, SOD, and MDA) activities were increased, while GST levels were decreased significantly compared to control. Histological investigations of treated snails for 6 weeks showed alterations in the normal structures of both ovotestis and digestive glands. The application of a mono-hormonal contraceptive drug is an environmentally safe method for controlling harmful land snails in spite of using chemical pesticides.