Background: Telenursing is a cost-effective and time-saving innovative technology that plays a vital role in client care by enabling access to nursing services at home. Aim of the study: Assess the knowledge and attitude of nursing school students regarding telenursing. Subjects and Methods; Research design: A descriptive, cross-sectional research design was utilized. Setting: The study was conducted at Sherief Omar, Fakous, Abu Kaber, Al-Husseiniyah, and Kafer Saker School. Subjects: A cluster sample of 400 students from these settings was used. Tools of data collection: Two tools were used in this study to collect the data. Tool I: A self- administered questionnaire which consisted of two parts to assess nursing students' socio-demographic characteristics and their knowledge about telenursing. Tool II: Questionnaire to measure attitude of nursing students regarding telenursing. Results: 41.75%of them had information about telenursing from social media, 52.25% had an average level of total knowledge, and 22.5% showed a good level of total knowledge. Furthermore, 44.25% had a positive attitude regarding telenursing. Conclusion: More than half of the nursing students demonstrated an average level of knowledge, while more than one-fifth exhibited good knowledge. Over two-fifths displayed a positive attitude toward telenursing. There was a highly significant positive statistical correlation between the total knowledge of nursing students regarding telenursing and their overall attitude. Recommendations: Educational programs should be developed and implemented to enhance nursing school students' knowledge and attitudes regarding telenursing, as well as establishing protocols for the integration of telenursing into nursing curricula and clinical practice.