Background: Treatment motivation is essential in the recovery process of patients with substance use disorder. Studies indicate that feelings of shame and guilt are among the selfconscious emotions that impact treatment motivation. Individuals with high levels of guilt and shame may find it difficult to forgive themselves, which can make the patients less likely to look for help. Aim of the study: Was to assess treatment motivation among patients with substance use disorder and its relation with self-conscious emotions and self-forgiveness. Subjects and Method; Research design: Descriptive correlational design was used to conduct this study. Setting: The study was conducted at El Azazi hospital for mental health in Abo Hamad City, Alsharkia Governorate, Egypt. Subjects: It included 153 patients with substance use disorder. Tools of data collection: Four tools were used to collect the data. Interview questionnaire which composed of socio-demographic and clinical data and Severity of substance use disorder, The Circumstances, Motivation, and Readiness (CMR) Scales, Test of Self-Conscious Affect-3 and Heartland Forgiveness Scale. Results: The study showed that the majority of studied sample had sever level of substance use disorder. The total mean score of treatment motivation was 76.22±7.45. The total mean score of selfconscious emotions (shame, guilt and blaming others) was 99.30±12.78. The total mean
score of forgiveness was 59.79± 8.27. There was significant positive correlation between forgiveness and treatment motivation. However, there was a significant negative correlation between forgiveness and self-conscious emotions. Conclusion: Patients' motivation for treatment was statistically significant positive predictor for forgiveness. Conversely, selfconscious affect was a statistically significant negative predictor for forgiveness. Recommendation: Developing training and educational programs for individuals with substance use disorder to enhance their treatment motivation, self-forgiveness and decrease level of self-conscious emotions.