Background: Servant leadership is unique of the greatest useful leadership approaches that work across healthcare settings. So, today's to lead healthcare nursing staff requires trend leadership approaches as servant leadership and respecting positive value for nursing profession that enable enthuse all levels of staff nurses to adopt an updated era of interconnection and dependability of health care environment shift for better whilst also struggling for superiority in the nursing and self-efficacy. Aim of the study: Was to investigate the relationship between servant leadership and Self -efficacy of staff nurses. Subjects and Methods; Research design: Descriptive correlational research design was adopted to carry out this study. Setting: The present study was conducted at Zagazig University hospitals. Subjects: Proportionate Stratified random sample of 375 staff nurses working at Zagazig university hospitals. Tools of data collection: Two tools were used for collecting data: Servant leadership assessment instrument and Self Efficacy Scale. Results: 61.9% of the studied nurses report that their leader had a high level of servant leadership. Also, 54.1% of them had moderate level of self-efficacy. Conclusion: There is highly statistical significant correlation between servant leadership and self-efficacy. Recommendations: Provide supportive management for healthcare professionals to acquire new skills and encourage a culture of learning from criticism and admitting mistakes, Foster an environment that encourages healthcare professionals to utilize their talents, generate new ideas, and actively contribute to problem solving.