Background: Psychiatric nurses are considered the main working group of hospitals, they are susceptible to have burnout and other psychological problems as depression as a result of heavy workload, long shift hours and the nature of the psychiatric working environment. Aim of the study was to assess burnout and depression among staff nurses. Subjects and Methods: Design: A descriptive correlational design was carried out. Setting: The study was conducted at El-Azazy Hospital for mental health in Abo Hammad city. Sample A convenient sample of 100 nurses. Tools for data Collection: Three tools were used to collect the data: I) a structured interview questionnaire, II) Maslach's Burnout Inventory, Human Services Survey (MBI-HSS) and III) Beck Depression Inventory (B D I). Result: The current study revealed that 93% were females, 57% had less than 10 years of experience, While 95% worked night shifts. Regarding burnout domains the highest level was to personal achievement 75.0% followed by emotional exhaustion 59.0%, and 23.0% of participants had depersonalization, while 19.0% of them had high level of total burnout. As well as, 66.0% had depressive symptoms, only 18.0% had sever level of depression. Whereas 48.0% of participants had mild level of depression. Conclusion: Less than one-quarter of nurses had high level of total burnout. Meanwhile, the majority of them had depressive symptoms ranging from mild to severe. There was a statistically significant positive correlation between depression and burnout. Furthermore, depersonalization burnout domain, problems with supervisors and peers were an independent positive predictors of depressive symptoms. Recommendations: Regularly assessment for factors which increase levels of burnout among psychiatric nurses, Implementing interventions to deal effectively with burnout.